Van Gaal, who took charge in May 2014, is looking to guide United to a return to Europe's elite club competition for the first time since 2013-14.
"You cannot say it is not any pressure because they are a good team," he said.
"We have to show our quality."
Faith in Rooney
United head into the game looking to maintain their 100% start to the season, having beaten Tottenham and Aston Villa in the Premier League.England captain Wayne Rooney has been leading the line for United but is waiting for his first goal of the campaign, and managed just one touch in the Villa area during Friday's 1-0 win.
Van Gaal, though, remains confident the goals will soon come for Rooney.
"I have always confidence in my players but we don't have only Wayne Rooney in the striker's position," said Van Gaal.
"We have Adnan Januzaj, he played in the striker's position in the USA. I have given him that chance and he has shown he can do that.
"We have Javier Hernandez, we have James Wilson - so I don't think we have a lack of strikers."
Defender Phil Jones, who has mild thrombosis, remains sidelined but Marouane Fellaini could start, with his suspension only applicable to domestic games.
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