Philippe Mexes headed in with his first touch after replacing Alex, who was stretched off after a head knock.
Carlos Bacca ran through to make it 3-0 before Ricardo Kishna's late reply.
Lazio had conceded only one goal at home in the league this season.
But they were outplayed by Sinisa Mihajlovic's improving side, who were handed the lead when Lazio goalkeeper Federico Marchetti parried the ball into the path of Bertolacci to open the scoring.
Mexes, who had not played this season because of injury, made an immediate impact as he headed home a 53rd-minute free-kick from Giacomo Bonaventura.
Bonaventura, the player with more assists in Serie A then anyone else, released Bacca to slot home the third and his seventh goal of the season.
However, 16-year-old goalkeeper Gianluigi Donnarumma was denied a clean sheet by Kishna's angled drive six minutes from time.
Elsewhere, Fiorentina returned to the top of table with an emphatic 4-1 victory over Frosinone .
Napoli's 0-0 draw at Genoa gave Fiorentina the chance to replace Inter Milan as leaders and Paulo Sousa's side took advantage with four first-half goals to go top on goal difference.
Struggling Bologna secured their third win of the season by beating Atalanta 3-0 to move within a point of Frosinone, who are just above the relegation zone.
The games between Carpi an d Verona and Udinese against Sassuolo both finished 0-0.
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